An "antioxidant defense network" exists inside the host cell to control ROS levels so as to allow useful functions whilst minimizing oxidative damage [reviewed in 20]. For this reason, antioxidants represent interesting molecules that have been proposed for the treat-ment of influenza.
Development of pharmacological strategies for Development of pharmacological strategies for mitochondrial disorders. Kanabus M(1), Heales SJ, Rahman S. Author information:(1)Clinical and Molecular Genetics Unit, UCL Institute of
Nov 15, 2013 · Ovarian cancer is characterized by high rates of metastasis and therapeutic resistance. Many chemotherapeutic agents rely on the induction of oxidative stress to cause cancer cell death, thus targeting redox regulation is a promising strategy to overcome drug resistance. We have used a tetracycline-inducible Ets-1 overeion model derived from 2008 ovarian cancer cells in the
Frontiers Neuroprotection Against Oxidative Stress Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related disorders, including neurodegenerative diseases and ischemic stroke, which are the major causes of dementia. The Nrf2-ARE (nuclear factor erythroid 2-related factor 2/antioxidant responsive element antioxidant) system, the primary cellular defense against OS, plays an essential role in neuroprotection
Mitochondrial dysfunction and oxidative stress in heart Dec 19, 2019 · Importantly, there has been increasing evidence that strategies targeting global ROS activity, such as trials with systemic administration of the antioxidants vitamin C
Jun 28, 2005 · This mini-review will focus on a chemopreventive strategy directed towards protection of DNA and other important cellular molecules by inducing de novo synthesis of phase II detoxifying or antioxidant genes via the Nrf2-ARE core signaling pathway. PMID:15914268 [Indexed for MEDLINE] Publication Types:Research Support, Non-U.S. Gov't; Review; MeSH terms
Oxidative stress and cellular pathways of asthma and This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma.
Pomegranate extracts and cancer prevention:molecular and Abstract. There is increased appreciation by the scientific community that dietary phytochemicals can be potential weapons in the fight against cancer. Emerging data has provided new insights into the molecular and cellular framework needed to establish novel mechanism-based strategies for cancer prevention by selective bioactive food components. The unique chemical composition of the pomegranate fruit, rich in antioxidant
Researchers have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies
Targeting senescent cells in translational medicine EMBO Targeting senescence metabolism through glycolysis blockade and attenuation of ATM, HDAC, FOXO4 activities as well as the PI3K cascade have also been reported as effective approaches. A second strategy is the activation of the immune system against senescent cells to stimulate their clearance.Molecular strategies for targeting antioxidants to 8 rows · Mar 01, 2015 · Lipophilic cations show great potential for the successful delivery of antioxidants to